Rapid corona testing through public-private cooperation
Medical staff at the Cisen Medical Foundation’s Molecular Diagnostic Laboratory in Seongdong-gu, Seoul, on October 10, examining the Corona 19 gene test. After two or three hours after the device placed in the compartment under the computer inserts a gene mixed with the reagent into the ‘real-time polymerase chain reaction (RT-PCR) test equipment, the results appear on the computer screen. This is the first time that the medical laboratory with the agency’s core diagnostic device has been released to the media. As the global new coronavirus infection (Corona 19) pandemic (large-scale proliferation) continues, South Korea has received the world’s attention by rapidly diagnosing corona infections on a large scale from the beginning of the crisis. yohan@donga How did korea’s corona 19 inspection competitiveness arise?
‘Oh! That’s what allowed for a large-scale inspection.’
The molecular diagnostic laboratory on the second floor of the Sisen Medical Foundation was visited by The Cheonho-do, Seongdong-gu, Seoul, on the morning of October 10. 55 genetically tested “real-time polymerase chain reaction (RT-PCR) testers were paired with computers.
On February 24, a single inspection agency inspected more than 107,000 cases a day, identifying 437 confirmed victims. On that day, he was responsible for about 60% of the domestic inspections. In recent years, inspections have been distributed to various agencies and reduced to more than 5,000 per day, but the cumulative number of inspections in Japan has been reduced to more than 70,000 (13 days) in two or three days.
Seegen is a 24-hour inspection agency that commissions 180,000 samples of 20,000 patients a day from more than 4,000 hospitals and clinics nationwide. When large-scale coronavirus diagnosis became the fire of the foot, we established a system that automated the entire process of diagnosis, and developed advanced technology to put the “target gene” of the diagnostic reagent into one tube three times the efficiency of conventional tests. The SCL Seoul Institute of Science and Technology in Gyeonggi Yong-in has been commissioned to conduct tests on 18,000 specimens from Finland. Finland also sent samples to neighboring Estonia, but chose Korea. The aircraft, carrying several boxes containing samples, flew to South Korea for more than 10 hours and was charged with inspection. It symbolizes the ability of the Corona test to be examined.
In Korea, there are “Big 5 Inspection Specialists”, such as The Sizen Medical Foundation SCL Seoul Institute of Science and Science, Lee Won Medical Foundation Green Cross Samgwang. They are all private institutions that seek profit. More than 100 medical institutions, including Seoul National University Hospital and Yonsei Severance Hospital, are conducting corona RT-PCR inspections. There was such a powerful inspection capability that the shincheonji shinto of Daegu, which should be inspected, did not matter at all, even if there were more than 10,000 worshippers.
Corona testing is possible only if you have a reagent. After corona 19 patients occurred in China on December 31 last year, and on January 12 this year, the National Center for Biological Information (NCBI) disclosed the gene sequence, and korean biotech companies began developing reagents. It was already a quick response before the first patient sat out in Korea on January 20.
Large-scale corona testing was possible because there is a national medical system that has nurtured and managed institutions that can perform advanced genetic testing and personnel. In the 1980s, the Department of Diagnostic Examination was independent from the department of pathology, and there are more than 1200 medical professionals and 10,000 clinical pathologists, including specialists. The specialization of diagnostics, which provided blood, urine, and biopsy results to clinicians who met and treated patients in person, played a decisive role in the corona situation.
The Korean Society of Diagnostic Tests has periodically managed the genetic testing diagnostic institutions through the certification of the “Molecular Diagnostic Laboratory”. Of the more than 2,000 testing agencies nationwide, only 100 have been genetically diagnosed. When rt-PCR scans were first started on March 7, 47 were selected as the primary testing agencies. The Centers for Disease Control and Prevention sent seven corona samplesamples (four positive, three negatives) to the right place. Just as a great athlete has had to be wide-open in sports, a high level of diagnostic medicine infrastructure has been a real hit with corona diagnostics.
On the day of January 20, when the first confirmed diagnosis was made, the Society of Diagnostic Tests formed the Corona Task Force (TF) and two days later met with jillbone officials to find a way to manufacture diagnostic reagents. Until then, there were six or seven known reagent recipes, including the World Health Organization (WHO) recommendations, but each had its own pros and cons. Jill bone and private medical experts have created a suitable testing protocol for Corona19. On 29 July, Jilbon unveiled the RT-PCR Protocol, a Korean reagent testing company. One expert likened it to a recipe for cooking, in which each vendor cooked their best menu.
Even with the capabilities of private biotech companies and inspection agencies, it is useless if the timing is missed due to the bottleneck of “administration and regulation.” Fortunately, the “Mers trauma” of 2016 was the basis for a quick response to the corona situation. In the following year, mers introduced a system to approve emergency use for new diagnostic reagents and testing methods in the event of a new infectious disease, which was triggered in a timely manner. This is why the January 27 Seoul Station Meeting is a turning point in the battle for corona.
On the last day of the New Year’s holiday, South Korea had four confirmed confirmers, just before the Corona flames began in earnest. It was also a day when the corona alarm was raised from ‘attention’ to ‘alert’. At 3 p.m., about 30 people gathered at the “Separate Room” meeting room on the 4th floor of Seoul Station’s history. The meeting was convened the day before. More than 20 officials from the Society of Quality and Diagnostic Tests and reagent manufacturers gathered in Seoul and the provinces.
At an emergency meeting on January 27, the Centers for Disease Control and Prevention delivered an emergency approval policy for corona19 diagnostic reagents at the Seoul Station ‘separate room’. The meeting ended in about an hour, but it quickly led to the development and approval of a large number of diagnostic reagents.
Four reagentcompanies submitted applications and reagents. Throughout the night, Jillbone reviewed the paperwork, and the prototype was crossed between The Vaginal Bone and three medical institutions for performance testing. It was an emergency approval, but a high-intensity examination was conducted, and on February 4, only one reagent was approved by Kozenbiotech. The examination, which normally took more than six months, was conducted at super speed.
On February 7, an RT-PCR scan was started with Kozen’s reagent. The existing ‘pan corona’ test sent the specimen scans to the 18-trial Institute of Health and Environment for the first test and then performed a second test in the vaginal bone. It took more than 24 hours and had a daily processing capacity of only about 160 people. Thousands of tests are now available in less than six hours. Following Seegen on 12 March, five companies, including The Solgent Esdy Biosensor Bioseum, received approval for emergency use by early March. Domestic diagnostic reagents have been able to perform more than 200,000 tests.
Kim Jin-yong, director of infectious medicine at Incheon Medical Center, the first doctor in Korea, came up with the first idea of a drive-through test. He posted on the Infectious Society’s site that in the event of a bioterrorism, the pest control agents would be able to apply a “drive-through” method to distribute preventive antibiotics to citizens without infection. On February 23, Dr. Son Jin-ho, director of The Chilgok Kyungbuk University Hospital in Gyeonggi Province, introduced this information to the “container inspection”. Three days later, Gyeonggi Goyang City began a “drive-thru” inspection in the public parking lot of Dukyang-gu, now widely known in the world. After the test erupted in the “telephone box”, a method of preventing the medical staff from wearing a level D protective suit that surrounded the entire body, the tester entered the telephone box and the tester evolved into a “walk-through” where the test was conducted outside the wind.
South Korea has been criticized for its response strategy, which is not even a genealogy of “opening the window and catching mosquitoes.” However, the rapid development of diagnostic reagents and the rapid response and public-private cooperation that emerged from emergency approval spurred the reins of the Corona window. By looking at this process, reagentcompanies and inspection agencies were able to see what creativity and enthusiasm would be used to help and incentivize them rather than to control the government.
I don’t think i can see this often. Many people point out that in the medical and biotechnology sectors, such as telemedicine and gene therapy, competitiveness is being oxidized by tight regulations. If this frustrating situation is not to persist, the Corona situation could be another opportunity. There is now a war of battle for corona drugs and vaccine development. Once again, we look forward to working with the public, such as in the corona test.
Professor Sung Moon-woo (member of the Corona TF Committee) Professor Lee Hyuk-min of Yonsei Medical School (Head of Corona TF) and Chairman of The Sisen Medical Foundation, Professor Sung Moon-woo Yi Bong-woo, Director of The Institute of Clinical Medicine, Sung Nak-moon, Director of The Institute of Clinical Medicine, Dr. Lee Seon-hwa, Director of Planning And Planning Kim Duk-hwan , Managing Director of Kozen Biotech Kim Su-bok , Director of SCL Seoul Institute of Science, Lim Hwan-seop , Senior Official of the Korea Food and Drug Administration Headquarters, Woo Young-taek, Spokesman for The Food and Drug Safety Administration (Kim Yong-suk, Head of The Foreign Cooperation Team at Seoul Station)
Bonhong@donga.com guja-yong editorial board member
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