(1) Red-haired monkey
(2) Genetically modified mice
(3) Supercomputer

1 Korea Institute of Biotechnology and infectious disease research center started researching therapeutics by developing two kinds of red-haired monkey corona 19 models with korean technology. 2 Genetically modified mice at the National Mouse Phenotype Analysis Group are smelling around with a curious expression. 3 Brookhaven National Laboratory supports research using supercomputers to identify the structure of the Corona 19 virus or therapeutic agent. Photo Source Wikimedia, Brookhaven National Institute for New Coronavirus Infection (COVID-19, Corona 19) Has been speeding up basic research on treatment and prevention. Behind the studies, which covered a variety of topics, from sarscoronavirus-2 (SARS-CoV-2) structure to patient case reporting, there are hidden trusts that have supported this. It is a supercomputer that supports complex data calculations on behalf of hundreds of scientists and experimental animals dedicated to supporting the development of safe vaccines and therapeutics. The first primate model developed with domestic technology entered the first therapeutic experiment this week. Supercomputers operated by domestic research institutes have also been supported by Corona 19 researchers.

○ Successful development of corona 19 primate model with domestic technology

Animal testing is the first step in confirming the effectiveness of the drug and vaccine in vivo. Animals that exhibit similar viral infections and symptoms are subjected to humans. Non-human primates are considered to be the most important contributors to the fact that they are the closest animals to humans. Red-haired monkeys are widely used.

In March, according to the National Institutes of Health (NIH) National Institutes of Infectious Diseases (NIAID), the monkey remained ill for 8-16 days after being infected with Corona 19. Monkeys do not develop as severe as humans, but many viruses are detected in the nose and throat, and symptoms such as lung infiltration is formed are similar to humans. The researchers concluded that “it can be used as a model for studying corona 19 infected animals with mild or moderate symptoms in humans.” Last month, Chinese biotech company Sinobaek conducted animal tests on eight red-haired monkeys to verify the effectiveness of its own vaccines. Remdesivir, who is known as a therapeutic agent, also underwent animal testing using red-haired monkeys in the middle of last month.

In Korea, the Korea Institute of Biotechnology and infectious disease research center recently developed two types of analysis models using red-haired monkeys that are infected with corona 19 and have symptoms. Earlier this month, the monkeys went into their first experiment scan for therapeutic candidates at a korean company. Ryu Chung-min, director of the Center for Infectious Diseases and Research, said on July 7, “Primate models with moderate and moderate symptoms are not uncommon in the world,” and “the development period was reduced to one-third of the usual two-thirds of the time, even after all the complex procedures considering the ethics of experimental animals in the Biosafety Class 3 (BSL3) facility were successful in two months.” Liu said, “We have selected a number of companies and will be experimenting with everything from cures to vaccines.”
○ Rats that play an important role in the development of protein-like proteins and corona19 virus research life sciences research are also active in the field of therapeutic and vaccine development. Rats can not be written directly to the infection experiment sascoronavirus-2 is a surface protein acetu (ACE2) that plays an important role when infected with epithelial cells are much different from people. However, in the wake of the 2003 SARS (SEVERE ACUTE RESPIRATORY Syndrome) epidemic, a team of researchers at the University of Iowa in the United States developed mice with ACE2 in humans and are also being used in infection research. The Jackson Institute of Medicine, an American medical laboratory that stores the mice’ embryos and sperm, recently rediscovered this genetically modified mouse and produced it through artificial insemination.

In Korea, the National Mouse Phenotype Analysis Group has developed a genetically modified mouse that has ace2 protein for a pre-clinical trial of therapeutic agents and vaccine development causing lung lesions. Sung Je-kyung, director of the National Mouse Phenotype Analysis Project (Professor of Veterinary Medicine, Seoul National University), said, “We are developing five corona 19 infection model mice in consideration of the virus mutation situation, and if we give birth to the first baby in May-June, it will likely be available to research institutes by August.”

Hamsters and weasels (ferrets) are also attracting new attention in the wake of the Corona 19 incident. Hamsterace2 protein is closer to humans than rats, and Ferret has the advantage that the physiology of the lungs is similar to humans.

○ Protein structure research, supercomputer to help detect therapeutic compound candidates

Supercomputers are responsible for the initial development of corona 19 therapeutics. It takes a lot of calculations to identify the structure of the virus protein and determine how it binds with various candidates. Because individual researchers cannot obtain these computers, laboratories with supercomputers have come to solve this problem.

The Open Science Grid (OSG) consortium is representative. Originally, the European Particle Physics Laboratory (CERN) was born to process the massive particle physics collision test data produced by the large-scale particle collision rheiner (LHC), in addition to particle physics supports research such as structural biology. In addition to the LHC team, more than 70 institutions are participating, including national laboratories and universities in the United States. We are currently supporting “Folding at Home”, a voluntary civic science project that reveals the three-dimensional structure of viral proteins in the wake of corona 19.

The Corona 19 High Performance Computing (HPC) consortium, a coalition of 37 organizations, including IBM, Amazon Web Services, Nvidia, google cloud, and 7 national laboratories and universities in the United States, has also supported 41 corona 19-related structural research, including protein and genetic material (RNA) stereoscopic analysis. In Korea, the Korea Institute of Science and Technology Information (KISTI) is supporting the use of “Nurion” as a supercomputer no. 5 for free. Small and medium-sized businesses, corona19 therapeutics and vaccine researchers only receive unlimited application.

Yun Shin-young, Reporter, Dong-ashilla@donga.com

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